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Fig. 12: fusion of acidosomes with phagosome membrane

Once the phagosome pinches off from the cytopharynx it and its docked acidosomes move rapidly to the posterior end of the cell. Here the acidosomes fuse with the phagosome membrane (cp) (for sidedness of label see Allen et al., J. Cell Sci. 108:1263-1274, 1995). The trigger for this regulated fusion has not been studied but, if like other forms of regulated membrane fusions, it probably involves a local increase in calcium. Fusion of acidosomes with the phagosome can begin to occur within seconds of phagosome release and appears to involve most acidosomes at the same time. This image shows that fusion necks of several acidosomes (arrowheads) appear simultaneously around the perimeter of a phagosome. EM taken on 6/9/78 by R. Allen with Hitachi HU11A TEM. Neg. 5,000X. Bar = 1µm. Published in part in Eur. J. Cell Biol. 35:149-155, 1984.
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